"We had no knowledge on meta‐analyses and were somewhat confused by the number of programs available. Most of them were not easy to use, not insightful and required a priori knowledge of metaanalyses statistics. There was one exception: Comprehensive Meta‐analysis. We downloaded the software and went through the easy‐to‐use tutorial. Within an hour we were performing our own metaanalysis! Our analysis was verified by our statistical department with excellent results, giving us further confidence to continue our analysis and resulting in an excellent paper in the top journal on pain research: Niesters et al., Do Sex Differences Exist in Opioid Analgesia? A Systematic Review and Meta‐ Analysis of Human Experimental and Clinical Studies. Pain, 2010, in press, doi:10.1016/j.pain.2010.06.012."

Albert Dahan, MD, PhD & Marieke Niesters, MD, MSc - Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands

"Comprehensive Meta‐Analysis Version 2 is really an easy‐to‐use software. It offers you a broad range of statistical, analytical and graphic capabilities to ensure valid meta‐analysis. It is accompanied by a selfexplanatory manual and tutorial. For anyone considering a faster and complete performance of metaanalysis, this software would be a clear first choice. In addition, the book and the online course “Introduction to Meta‐analysis” have been ideal resources in my case, for a complete understanding of this approach. Both strongly recommendable…!!!."

Dr. Miguel Santibáñez Margüello, M.D., PhD - Researching Support Unit, IFIMAV – Fundación Marques de Valdecilla, Cantabria University, Nurse School, Santander Spain