Version 2 software

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Comprehensive Meta-Analysis

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Comprehensive Meta-Analysis (CMA) is a powerful computer program for meta-analysis. The program combines ease of use with a wide array of computational options and sophisticated graphics.


"My experience with Comprehensive Meta‐analysis is highly positive. The spreadsheet interfaces for data entry are very intuitive. They handle an astonishing wide array of indices and formats for effect sizes, including the possibility of entering them in the spreadsheet by copy‐and‐paste. The exploratory phase is easily performed thanks to a variety of facilities, as cumulative meta‐analysis, sensitivity analysis by the “one‐study‐removed” procedure, and subgroup analysis, among others. It covers all basic fixed and random effect models and provides high‐quality graphical outputs for reports. The tutorial and the manual are really helpful and friendly. In short, Comprehensive Meta‐analysis is my favorite tool both for performing and teaching meta‐analysis."

Professor Juan Botella - Autonomous University of Madrid


"We had no knowledge on meta‐analyses and were somewhat confused by the number of programs available. Most of them were not easy to use, not insightful and required a priori knowledge of metaanalyses statistics. There was one exception: Comprehensive Meta‐analysis. We downloaded the software and went through the easy‐to‐use tutorial. Within an hour we were performing our own metaanalysis! Our analysis was verified by our statistical department with excellent results, giving us further confidence to continue our analysis and resulting in an excellent paper in the top journal on pain research: Niesters et al., Do Sex Differences Exist in Opioid Analgesia? A Systematic Review and Meta‐ Analysis of Human Experimental and Clinical Studies. Pain, 2010, in press, doi:10.1016/j.pain.2010.06.012."

Albert Dahan, MD, PhD & Marieke Niesters, MD, MSc - Department of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands